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Structure and functional dynamics characterization of the ion channel of the human respiratory syncytial virus (hRSV) small hydrophobic protein (SH) transmembrane domain by combining molecular dynamics with excited normal modes
(Springer, 2016-12-01)
The human respiratory syncytial virus (hRSV) is the major cause of lower respiratory tract infection in children and elderly people worldwide. Its genome encodes 11 proteins including SH protein, whose functions are not ...
1H, 15N, and 13C resonance assignments of the SH3-like tandem domain of human KIN protein
(2021-10-01)
KIN is a DNA/RNA-binding protein conserved evolutionarily from yeast to humans and expressed ubiquitously in mammals. It is an essential nuclear protein involved in numerous cellular processes, such as DNA replication, ...
Characterization of human SH2 domain-containing protein 4A (SH2D4A) in HeLa cells
(Federation Amer Soc Exp Biol, 2017-04-01)
The redundancy of NMR restraints can be used to accelerate the unfolding behavior of an SH3 domain during molecular dynamics simulations
(BioMed CentralLondon, 2011-11)
Background:
The simulation of protein unfolding usually requires recording long molecular dynamics trajectories. The present work aims to figure out whether NMR restraints data can be used to probe protein conformations ...
Estudo da Estrutura da Proteína SH do Vírus Sincicial Respiratório Humano: análise funcional da estrutura pentamérica por ferramentas de bioinformática
(Universidade Estadual Paulista (Unesp), 2013-05-24)
The human Respiratory Syncytial Virus (hRSV) is the major cause of lower respiratory tract illnesses in children and elderly people worldwide. Its genome encodes 11 proteins including the surface protein F, G and SH which ...
NMR assignment of free 1H, 15N and 13C-Grb2-SH2 domain
(2019-10-15)
Growth factor receptor-bound protein 2 (Grb2) is an adaptor protein composed of three domains, an N-terminal SH3 (nSH3), SH2 and a C-terminal SH3 (cSH3) domains. This multi-domain protein has been reported to be a key ...
Estudo por dinâmica molecular e ressonância magnética nuclear de Viroporinas: análise da estrutura e do mecanismo de portão da proteína SH (HRSV) e da proteína M2 (vírus Influenza)
(Universidade Estadual Paulista (Unesp), 2018-01-29)
As proteínas SH do HRSV e M2 do IAV são membros das viroporinas, uma família de proteínas virais pequenas de membrana. A proteína SH tem 64 resíduos de aminoácidos e uma estrutura pentamérica composta por alfa-hélice ...
Obtención de hidrolizados de proteínas de vísceras de trucha arcoíris (Oncorhynchus mykiss) con propiedades bioactivas y/o funcionales
(Grupo de Nutrición y Tecnología de AlimentosMedellín, Colombia, 2021)
Dinâmica estrutural da proteína adaptadora Grb2, seu domínio SH2 e a interação com cumarina por ressonância magnética nuclear e fluorescência
(Universidade Estadual Paulista (Unesp), 2019-04-12)
As células são submetidas a um constante e preciso controle de sobrevivência, crescimento, diferenciação e apoptose. Durante o processo de proliferação celular, estas também estão sujeitas a erros que podem gerar perda de ...